Both Christian Walton and Tosin Adarabioyo had a big impact on the game as Rovers returned to winning ways on Saturday afternoon.
Adarabioyo's first senior goal got Rovers back on level terms with two minutes remaining before John Buckley's dramatic late winner in front of the Blackburn End.
There was still to be one final chance for the visitors, with Walton making a huge save to deny Wednesday skipper Sam Hutchinson after substitute Fernando Forestieri's deflected strike rattled the post.
They were big moments for Tony Mowbray's men, and the boss was pleased with the impact from both of Rovers' loan stars.
“There were lots of good performances today," Mowbray reflected to iFollow Rovers after the great win against Garry Monk's high-flyers.
“For Christian to make that amazing save right at the end, it was great for him and it kept it at 2-1 instead of 2-2.
“He deserves credit, because he was at fault for the first goal at Preston last week in my opinion and for him to help us achieve the result today is good.
“I was pleased for lots of them today. Tosin scored a goal and he was magnificent.
“We’ve struggled against teams who play direct football against us and today I told him he had to stand up and be counted and be the man who heads the ball.
“It’s underestimated how important heading the ball back over the halfway line from goal-kicks is and that’s what he did for us today and scored as well.
“So I’m delighted with him.”