Rovers suffered defeat in their first home game of the season as an impressive Chelsea side confidently beat Damien Johnson's young side.
The visitors played some neat football throughout and opened the scoring early on through Billy Gilmour before second half strikes from Daishawn Redan and Luke McCormick sealed a big victory for the Londoners.
Rovers struggled to break down a Chelsea defence which included the highly-rated Ethan Ampadu in at centre back and had nothing to show for their efforts on a cool night in Leyland.
Johnson made two enforced changes, with Tyler Magloire injured and Charley Doyle suspended. That resulted in Ben Paton and Joe Nuttall coming into the side against the Blues.
The visitors got themselves a dream start as Gilmour tapped home from close range after a great run and cross from captain McCormick played him in after just two minutes.
Rovers responded well and could have equalised just seconds later but after a great one-two involving Nuttall and Lewis Hardcastle, Chelsea stopper Jamie Cumming spread himself well to deny the Rovers skipper a quick-fire equaliser.
Willem Tomlinson tried his luck 16 minutes in as Rovers continued to push forward, but saw his 25 yard strike held down low by Cumming.
Chelsea were pushing for a second goal of the half, and after McCormick let fly from range, Fisher was down to save before smothering Redan's follow up attempt.
With two minutes until the break, George McEachran's inviting ball in found the towering Ampadu at the back post and a combination of Andy Fisher and Hayden Carter denied the former Exeter man a second goal for the away side.
Ten minutes into the second half Chelsea made it 2-0 and it came in excellent style. Callum Hudson-Odoi played the ball infield and after a dummy from the impressive McCormick, Redan was there to take a touch and rifle into Fisher's bottom right-hand corner.
Tariq Lamptey went for goal from range with 18 minutes to go and saw his thunderous drive crack the crossbar as the visitors searched for more at Leyland.
With eight minutes remaining, 2-0 became 3-0 and again it was a lovely, well worked move by the visitors to completely kill the game off. Substitute Charlie Brown wriggled free down the right and McCormick got a goal his performance deserved by smashing home from close range.
In truth, it was a deserved victory for the London side, who showed plenty of class throughout the clash to inflict a rare defeat on a Rovers side who are used to winning games.
Johnson's side will be aiming to get back on track on Monday night when they travel to Leicester City for a third Premier League 2 game of the season.
Rovers: Fisher, Buckley, Evans, Tomlinson, Carter, Grayson, Mols (Vale, 70), Hardcastle (c), Nuttall, Butterworth (Mansell, 82), Paton (Simmonds, 67).
Unused substitutes: Byrne, Thompson.
Booked: Buckley, 35, Carter, 41, Grayson, 54, Tomlinson, 89.
Chelsea: Cumming, Lamprey, Colley, Ampadu, Guehi, McEachran, McCormick (c), Gilmour (Uwakwe, 68), Redan (Brown, 68), Hudson-Odoi, Castillo.
Unused substitutes: Ziger, Taylor-Crossdale, Mola.
Goals: Gilmour, 2, Redan, 56, McCormick.a
Referee: Ms R. Welch