Rovers boss Tony Mowbray expects to be without Corry Evans and Paul Downing for the midweek match against Plymouth Argyle.
The duo were ruled out of Saturday's trip to Oldham Athletic through injury and are unlikely to be fit to face the Pilgrims at Ewood Park on Tuesday night.
Evans returned from international duty with Northern Ireland with an ankle injury, whilst Downing hasn't trained for the past fortnight having picked up a hamstring strain in Rovers' last Ewood outing against Gillingham.
And Mowbray wasn't prepared to use their absence as an excuse for the disappointing defeat at Boundary Park.
"You have to put up with injuries, they're part and parcel of the game," said the manager.
"Paul Downing was never going to make it. He's had a hamstring problem since the Gillingham game.
"Corry is a frustration for us, of course. He trained on Thursday and then he was too sore to finish the session, so he didn't make it because he picked up an injury in the international break.
"They probably won't make Tuesday. It will be difficult, but let's wait and see. You never know with the injuries that they've got.
"For Corry, another couple of days might give him a better chance.
"With Paul Downing, you have to be very careful with hamstrings, not to rush them back, otherwise it could be another six to eight weeks, so we need to protect him."