Rovers boss Tony Mowbray has named one change to the side who defeated Bury at the weekend.
Corry Evans returns from suspension and comes in for Peter Whittingham, who drops to the bench.
Elliott Bennett makes his 50th league start for Rovers.
There is a familiar face in goal for the hosts as Simon Eastwood - who made 20 appearances in three years at Ewood Park - starts for Oxford.
OXFORD: Eastwood, Tiendalli, Martin, Ledson, Thomas, Payne, Ruffels, Henry, Rothwell, Ricardinho, Mousinho (c).
SUBS: Shearer, Fernandez, Obika, Mowatt, Williamson, Carroll, Napa.
ROVERS: Raya, Nyambe, Downing, Mulgrew (c), Williams, Smallwood, Evans, Bennett, Antonsson, Dack, Nuttall.
SUBS: Leutwiler, Ward, Caddis, Whittingham, Harper, Graham, Samuel.