Rovers have made three changes from the side that drew with Rotherham United at the weekend.
Connor Mahoney is handed his first league start of the season, he comes in along with fellow midfielders Danny Guthrie and Hope Akpan.
The men to make way are Ryan Nyambe, Craig Conway and Liam Feeney who all drop to the bench.
The Owls make just the one change as Adam Reach replaces Fernando Forestieri.
SHEFF WED: Westwood, Hunt, Loovens (c), Sasso, Fox, Wallace, Bannan, Hutchinson, Reach, Winnall, Rhodes.
Subs: Wildsmith (GK), Jones, Fletcher, Abdi, McManaman, Palmer, Forestieri.
ROVERS: Steele, Lowe (c), Lenihan, Mulgrew, Williams, Bennett, Akpan, Guthrie, Mahoney, Gallagher, Graham.
Subs: Raya (GK), Feeney, Emnes, Nyambe, Tomlinson, Brown, Conway.