Rovers have made four changes from the side that face Sheffield Wednesday in midweek.
Into the starting XI come Gordon Greer, Liam Feeney, Craig Conway and Marvin Emnes as Sam Gallagher misses out through injury, Elliott Bennett and Hope Akpan are suspended and Connor Mahoney drops to the bench.
Jose Mourinho's side sees seven changes from the side that defeated Saint Etienne on Thursday.
ROVERS: Steele, Lowe (c), Greer, Lenihan, Williams, Feeney, Guthrie, Mulgrew, Conway, Emnes, Graham
Subs: Raya (GK), Stokes, Hendrie, Nyambe, Tomlinson, Mahoney, Brown.
MAN UTD: Romero, Rojo, Martial, Lingard, Carrick (c), Young, Rashford, Herrera, Mkhitaryan, Darmian.
Subs: Henderson (GK), Bailly, Pogba, Mata, Ibrahimovic, Shaw, Schweinsteiger.