Rovers have made three changes from the side that faced Brighton at the weekend.
Into the side come Hope Akpan against his former club, Liam Feeney and Sam Gallagher, with Danny Guthrie, Marvin Emnes and Lucas Joao all dropping to the bench.
Tonight's hosts also make three changes from their match on Saturday evening as Adrian Popa, Reece Oxford, and Jordon Mutch come in for Jordan Obita, Garath McCleary, and Daniel Williams.
READING: Al Habsi, Gunter, Beerens, Swift, Moore, Kermogant, Blackett, Popa, Kelly, Oxford, Mutch.
Subs: Jaakkola (GK), Mendes, McCleary, Ilori, Williams, Watson, Grabban.
ROVERS: Steele, Nyambe, Lenihan, Mulgrew, Williams, Conway, Lowe (c), Akpan, Feeney, Bennett, Gallagher.
Subs: Raya (GK), Hoban, Emnes, Joao, Guthrie, Mahoney, Brown.