Rovers boss Owen Coyle has confirmed that Derrick Williams will be out of action for up to six weeks.
The full-back sustained a hamstring injury against former club Bristol City last weekend and now faces a spell on the sidelines.
"Derrick has a grade one hamstring so he'll be out for four to six weeks," revealed the manager.
"We've not been blessed by luck in that department in terms of injuries, so it is disappointing as he has played very well for us since coming in.
"So unfortunately we'll miss him for a period of time now so we just have to adjust with the players that we do have and look to get ourselves ready for a big game on Saturday."
Anthony Stokes is fit again after missing out last weekend due to illness, whilst Gordon Greer is back in full training. Danny Graham could come into contention if he comes through training on Friday.
The Rovers boss added: "Gordon Greer has the best chance, he trained with the group today. Danny Graham was out on the grass and did a little bit so we may have a look at that tomorrow as to whether he is able to be involved, but he would have to train with us on Friday for that to be an option.
"Anthony Stokes is now over his illness so he is fit and has trained all week, so that is a good boost to the striking department. So we do have a couple of options that we didn't have the other week."
Tickets for Saturday's match will be on sale until the 5.30pm kick-off. Priced from £22 for Adults, £14 Concessions and £9 for Juniors aged 17 and under.
Buy online today at www.eticketing.co.uk/onerovers and collect from the Roverstore collection point, or by in store at Ewood Park, or call 01254 372000.
Rovers supporters are reminded that upon entry into the stadium, they agree to adhere to the Ground Regulations.
Any supporters who contravene these rules could face potential criminal prosecution and/or banning orders imposed by the club.
The club urges all supporters to behave in an appropriate manner and to show their full support to the team.