Rovers make five changes from the side that lost at home to Leeds United on Saturday.
Adam Henley, Corry Evans, Matt Grimes, Chris Brown and Simeon Jackson all come into the starting eleven for the Portman Road match.
Ben Marshall, Tony Watt, Jordi Gomez, and Darragh Lenihan all drop to the substitute's bench, whilst Danny Graham misses out with a back complaint.
The hosts make two changes from their weekend defeat as Brett Pitman and former Rover Jonathon Douglas come into the side. Kevin Bru and Ben Pringle the men to make way.
IPSWICH: Bialkowski, Knudsen, Chambers (c), Smith, Berra, Skuse, Murphy, Pitman, Hyam, Sears, Douglas.
Subs: Gerken (GK), Pringle, Bru, Digby, Toure, Varney, Foley.
ROVERS: Steele, Henley, Duffy, Hanley (c), Spurr, Evans, Akpan, Grimes, Bennett, Jackson, Brown.
Subs: Raya (GK), Watt, Marshall, J. Gomez, Ward, Lenihan, Conway.