Boss Paul Lambert felt the sending off of Chris Taylor was the key moment as Rovers went out of the FA Cup at the hands of West Ham United.
Rovers started strongly, taking the lead courtesy of a Ben Marshall strike, but goals from Victor Moses and Dimitri Payet gave the Hammers a half-time lead.
The home side started the second half strongly but then saw Taylor sent off for a second bookable offence and from that point on it was one-way traffic as the Premier League side showed their quality to score three further goals to book their place in the quarter-finals.
"I thought the sending off changed the whole course of the game, it killed us," Lambert told Radio Rovers.
"We were well in the game, we started excellently, we got a really good goal, but then we lose a poor first goal, Jason has to save it he knows that.
"The second goal is a world-class free-kick from a top player but we were well in the game.
"We started the second half really well and got on top of the game but then there's the sending off.
"For 55 minutes when it is 11v11 we were well in it.
"But to play a Premier League team with ten men for that length of time and the quality that they have got, it is hard.
"We kept on going, we never capitulated, but they are just a top, top side."
Rovers are back in action in the league this Wednesday night when they travel to the iPro stadium to take on Derby County.