Paul Lambert has handed a first start to Connor Mahoney, three seasons after the forward made his debut as a 16-year-old.
Mahoney is one of five changes from the side that lost at the weekend, with Elliott Ward, Corry Evans, Jason Lowe and Hope Akpan also coming into the side.
Jordi Gomez, Shane Duffy, Elliott Bennett, and Simeon Jackson drop to the bench, Matt Grimes doesn't make the 18.
Forest have named an unchanged XI following their goalless draw at Rotherham on Saturday.
FOREST: De Vries, Lichaj, Jokic, Mills, Lansbury (c), Fox, Mendes, Gardner, Blackstock, Tesche, Osborn.
Subs: Evtimov (GK), Cohen, Assombalonga, Vaughan, O'Grady, Burke, Worrall.
ROVERS: Steele, Lowe, Ward, Hanley (c), Kilgallon, Akpan, Evans, Lenihan, Marshall, Graham, Mahoney.
Subs: Raya (GK), Brown, Gomez, Williamson, Duffy, Bennett, Jackson.