Adam Henley earned a first cap and Tom Lawrence made his first start for Wales on Friday evening.
Defender Henley came on as a second half substitute as Wales began their preparations for next summer's Euro 2016 finals with a narrow 3-2 loss to the Netherlands.
Lawrence started the match at the Cardiff City Stadium as Bas Dost headed the Dutch in front before Joe Ledley equalised after Joe Allen's penalty had been saved.
Ajen Robben put Holland back in front but Emyr Huws levelled, before the Bayern Munich frontman grabbed his second of the match nine minutes from time to seal the win.
Shane Duffy wasn't involved as the Republic of Ireland drew their qualifying play-off 1st leg with Bosnia & Herzegovina 1-1 in Zenica.
Robbie Brady put the Irish in front on 82 minutes, but Edin Dzeko levelled just three minutes later.
Northern Ireland won once more as they defeated Latvia 1-0 in Belfast thanks to a goal from Steven Davis. Corry Evans played the whole of the second half at Windsor Park.
But there was disappointment for the Republic of Ireland's Under-21s as they went down 3-1 away to Lithuania.
Darragh Lenihan captained the Irish as they suffered only their second defeat of their qualifying programme.
In Kingston, Lee Williamson was an unused substitute as Jamaica began the fourth round of their World Cup 2018 qualifying campaign with a 2-0 home defeat at the hands of Panama.