Rovers make seven changes from the side that defeated Sheffield Wednesday in midweek.
Simon Eastwood, Alex Baptiste, Markus Olsson, Craig Conway, Corry Evans, Tom Cairney and Rudy Gestede all come into the side for the Anfield clash.
Jason Steele, Tommy Spurr, Chris Brown, Jordan Rhodes, Chris Taylor and Doneil Henry drop to the bench, whilst Jay Spearing is cup-tied.
For the hosts they make two changes from their Wednesday win over Burnley, as Glen Johnson and Lazar Markovic return to the starting eleven. Joe Allen and Alberto Moreno the men to miss out.
LIVERPOOL: Mignolet, Johnson, Lovren, Coutinho, Henderson (c), Sturridge, Lallana, Can, Sterling, Skrtel, Markovic.
Subs: Ward (GK), Toure, Lambert, Moreno, Sakho, Williams, Balotelli.
ROVERS: Eastwood, Henley, Baptiste, Kilgallon (c), Olsson, Conway, Evans, Williamson, Marshall, Cairney, Gestede.
Subs: Steele (GK), Spurr, Brown, Rhodes, Taylor, Henry, Lenihan.