Rovers make five changes from the side that lost 1-0 at home to Wolverhampton Wanderers last time out.
Jason Lowe, Matt Kilgallon, Corry Evans, Craig Conway and Chris Brown all come into the starting eleven.
Alex Baptiste, Lee Williamson, Chris Taylor and Shane Duffy drop to the bench, whilst Rudy Gestede didn't travel to the DW Stadium.
The hosts make three changes with Martyn Waghorn, Ben Watson, and William Kvist starting.
WIGAN: Carson, Perch (c), Barnett, Ridgewell, Taylor, Watson, Forshaw, McCann, Kvist, Waghorn, McClean.
Subs: Nicholls (GK), Boyce, Huws, Maloney, Fortune, Delort, Cosgrove.
ROVERS: Steele, Lowe, Hanley (c), Kilgallon, Olsson, Evans, Cairney, Conway, Marshall, Rhodes, Brown.
Subs: Eastwood (GK), King, Dunn, Baptiste, Williamson, Taylor, Duffy.