Rovers hand a debut for new loan signing Tom Lawrence, who joined yesterday from Leicester as two changes are made from the side that drew with Cardiff City.
The other change sees Danny Guthrie come into the starting eleven.
The two players missing out are Jason Lowe and Adam Henley who were both taken ill overnight, meaning there are just six substitutes named on the bench.
BRIGHTON: Stockdale, Salter, Greer (c), Huenemeier, Stephens, Kayal, Baldock, Hemed, Bong, Murphy, Lua Lua.
Subs: Maenpaa (GK), Ince, Forster-Caskey, Rosenior, O'Grady, Dunk, March.
ROVERS: Raya, Marshall, Hanley (c), Duffy, Spurr, Lawrence, Guthrie, Akpan, Conway, Delfouneso, Koita.
Subs: Steele (GK), Kilgallon, Olsson, Williamson, Evans, Barrow.