Rovers make just the two changes from the side that defeated Leeds United last time out.
With Jason Steele ineligible and Tom Cairney suspended, both changes are enforced as Simon Eastwood and Ryan Tunnicliffe come into the starting XI.
For the home side they make five changes from the side that drew away with Wigan last time out as Fredericks, Whitehead, Omeruo, Vossen and Bamford replace Gibson, Nsue, Clayton, Reach and Kike.
MIDDLESBROUGH: Konstantopoulos, Leadbitter (c), Tomlin, Omeruo, Friend, Vossen, Ayala, Bamford, Fredericks, Adomah, Whitehead.
Subs: Mejias, Gibson, Kike, Reach, Nsue, Veljkovic, Wildschut.
ROVERS: Eastwood, Baptiste, Hanley (c), Duffy, Olsson, Tunnicliffe, Evans, Williamson, Marshall, Gestede, Rhodes.
Subs: Kean (GK), Henley, Dunn, Brown, Varney, Taylor, Conway