Whilst his counterpart Gary Johnson described it as their 'game of the century', Bowyer has similar feelings, as he expects the game against the Glovers to be their toughest of the campaign to date.
"First and foremost we've got to focus on this one because this game is our toughest of the season," said the manager.
"Yeovil are fighting for their lives. They've proved already this season that they can go away and pick up points.
"They drew away at Leicester, they've drawn with Bournemouth, and I've seen them draw away at Wigan.
"So this is going to be the toughest game of our season so far and we've got to make sure that we are right and do everything that we can to make sure that we perform to the level that we've set.
"We know it is going to be extremely difficult, we have to make sure that we are as competitive as possible.
"Then we'll look at the next game after."
Tickets for the Yeovil match will be on open sale until the 3.00pm kick-off this Friday. Prices are from £15 Adults, £10 Seniors and from £5 Juniors. Why not book your tickets online today at www.onerovers.co.uk
and collect from the Blackburn End collection point on the day of the game.