Gary Bowyer makes one change from the side that face Cardiff City on the opening day of the season.
With Matt Kilgallon missing out with a back injury, Josh King comes in as Rovers shuffle their squad.
Jason Lowe moves from midfield to right back with former Seasider Alex Baptiste partnering Grant Hanley in the centre of defence.
Josh King will operate on the right with Cairney in the centre of midfield.
BLACKPOOL: Lewis, McMahon (c), Clarke, Daniels, Oriol, Perkins, Lundstram, Mellis, Cywka, Delfouneso, Miller.
Subs: Parish (GK), Dielna, Dunne, Rentmeister, Zenjov, Davies, Zoko.
ROVERS: Robinson, Lowe, Baptiste, Hanley (c), Olsson, King, Evans, Cairney, Conway, Rhodes, Gestede.
Subs: Eastwood (GK), Dunn, Marshall, Varney, Williamson, Taylor, O'Connell.