Football returns to Ewood Park after the break with the manager sweating on the fitness of Jordan Rhodes, Grant Hanley and Josh King who all picked up knocks for their countries.
Speaking on Thursday Bowyer said: "I think we've suffered more than anybody over the international breaks, but that is part and parcel of it I suppose and we've got to pick everybody up and get on with it.
"Obviously when your players go away on international duty you are always sitting by the phone and he's done it to my twice now has Jordan where he's panicked me.
"Fortunately he got back, we got it scanned and the medical team have been brilliant."
Hanley and King also returned early from duty but Bowyer hopes the pair will be available.
"Grant came back with a groin injury, but he was sensible enough to get himself straight back down the road and checked out by the medical team.
"So we are hopeful that him and King can come back into the squad on Saturday."
Lee Williamson has shaken off the hamstring strain that forced him out of the Brighton match last time out, the extra time off for once helping Rovers.
Bowyer added: "That's the experience that Williamson has got in a sense that he felt his hamstring but rather than push and it go completely he came off and fortunately for us he has responded very well.
"That is probably the one positive of the international break is it has given him a bit more time and he's back fit and ready to go."
DJ Campbell serves the last of his three-match ban, Paul Robinson and Corry Evans are continuing their rehabilitation.
Another player on the road to recover is Ruben Rochina. The Spaniard is back in full training and building up his fitness.
"Ruben's fitness levels are not bad, but we've just got to be careful with him that we don't rush him and the expectancy on him," added the manager.
"He's yet to play a full 11v11 game, we had an in-house game on Tuesday in which he played 30 minutes of that. We saw bits of Ruben magic and there was obvious rustiness from him because that was his first 11v11.
"So we won't want to be stupid with him because what we don't want to is risk further injury and him being out of the team again. So it is a case of just building his fitness up."
Tickets for Saturday's game are currently on open sale priced from £19 Adults, £12 Seniors and £7 Juniors. Book online today at www.onerovers.co.uk
and collect from the Blackburn End collection point ahead of the 3pm kick-off.